Rho dependent Termination

● This type of termination occur in Prokaryotes for termination of transcription. 

◇ Transcription = Synthesis of RNA from DNA.

● Dna which have such a termination sequence which terminates the transcription only in presence of rho factor are called rho dependent termination.

● This termination sequence is rich in C but devoid of G .This types of sequence is necessary for function rho protein .

 ● Rho protein binds with mRNA which is elongated by rna polymerase at rut site (rho utilization site) and then rho protein moves from 5' to 3' end .

● When RNA polymerase reaches rho dependent termination sequence then rho protein shows its helicase activity and unwind DNA-RNA hybrid.

● This will disrupt and terminate transcription bubble and new synthesized mRNA is released.

 (Helicase is a enzyme that can unwind the dna strand or we can say breaks H bonds present in between the double helix of DNA )

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